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Metabolic Regulation of Kisspeptin

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Book cover Kisspeptin Signaling in Reproductive Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 784))

Abstract

Body energy balance and metabolic signals are important modulators of puberty and reproductive function, so that perturbations of metabolism and energy reserves (ranging from persistent energy insufficiency to morbid obesity) are frequently linked to reproductive disorders. The mechanisms for the tight association between body metabolic state and reproduction are multifaceted, and likely involve numerous peripheral hormones and central transmitters. In recent years, a prominent role of kisspeptins in the central pathways responsible for conveying metabolic information into the brain centers responsible for reproductive control, and specifically GnRH neurons, has been proposed on the basis of a wealth of expression and functional data. In this chapter, we will summarize such evidence, with special attention to the potential (direct and/or indirect) interaction of leptin and kisspeptin pathways. In addition, other potential metabolic modulators of kisspeptin signaling, as well as some of the putative molecular mechanisms for the metabolic regulation of Kiss1 will be briefly reviewed. Conflictive data, including those questioning an essential role of Kiss1 neurons in mediating leptin effects on the reproductive axis, will be also discussed. All in all, we aim to provide an integral and balanced view of the physiological relevance and potential mechanisms for the metabolic control of the kisspeptin system, as important pathway for the integral regulation of energy balance, puberty onset, and fertility.

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Acknowledgments

The authors are indebted with the members of the research team at the Physiology Section of the University of Cordoba, who actively participated in the generation of experimental data discussed herein. The work from the authors’ laboratory summarized in this article was supported by grants BFU 2005-07446, BFU 2008-00984, and BFU2011-­25021 (Ministerio de Economía and Competitividad, Spain; covered in part by EU-FEDER funds), grants from Instituto de Salud Carlos III (Red de Centros RCMN C03/08 and Project PI042082; Ministerio de Sanidad, Spain), and EU research contracts EDEN QLK4-CT-2002-00603 and DEER FP7-­ENV-2007-1. CIBER is an initiative of Instituto de Salud Carlos III (Ministerio de Sanidad, Spain).

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Authors and Affiliations

  1. Department of Cell Biology, Physiology and Immunology, University of Cordoba, Avda. Mendndez Pidal s/n, 14004, Cordoba, Spain

    Juan Manuel Castellano & Manuel Tena-Sempere M.D., Ph.D.

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  1. Juan Manuel Castellano
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  2. Manuel Tena-Sempere M.D., Ph.D.
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Correspondence to Manuel Tena-Sempere M.D., Ph.D. .

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Editors and Affiliations

  1. , Department of Reproductive Medicine, University of California, San Diego, La Jolla, 92093, California, USA

    Alexander S. Kauffman

  2. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Hackett Drive, Nedlands, 6009, West Australia, Australia

    Jeremy T. Smith

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Castellano, J.M., Tena-Sempere, M. (2013). Metabolic Regulation of Kisspeptin. In: Kauffman, A., Smith, J. (eds) Kisspeptin Signaling in Reproductive Biology. Advances in Experimental Medicine and Biology, vol 784. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6199-9_17

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