Top Government scientist says there is 'enough' data to approve Oxford's Covid vaccine despite row over the 'shaky science' behind promising jab

  • MHRA will assess the Oxford/AstraZeneca vaccine as soon as it gets full data
  • Race is now on between Oxford and Pfizer for first approval in the UK
  • Same process began on Pfizer's '95% effective' jab last week after trial results
  • But confusion over efficacy of AstraZeneca jab has led firm to start a new trial
  • Best results were seen in a group given the wrong dose by accident, study shows

There is enough data showing Oxford University's coronavirus vaccine works to approve the jab next month, one of Number 10's top scientists claimed today amid a row over the 'shaky science' behind its promising results.

The expert, who wished to remain anonymous, said there was 'nothing unusual' or worrying about the studies, despite independent scientists voicing concerns about about their methods.   

Officials last night asked the Medicines and Healthcare products Regulatory Agency (MHRA) to consider giving emergency approval for the jab, so that it could be given out from next month if it is deemed safe and effective.

The senior Government source added they had faith the UK's drugs watchdog would 'look carefully' at the data, adding there is 'probably enough there overall to approve' it. 

Confusing trial results from Oxford found under-55s accidentally given too little of the vaccine actually had better protection from coronavirus than those who got the full doses, making it unclear how effective the vaccine really is.

The MHRA is doing the same analysis of Pfizer's jab and 'emergency approval' does not bypass any safety checks but means it can be given out as soon as regulators are satisfied, rather than waiting for official paperwork to be finalised. This was made possible by a specific new law brought in during the summer. 

Oxford's trial results this week suggested the vaccine is somewhere between 62 and 90 per cent effective, depending on the dosage people are given.

The jab turned out to be most effective among 2,741 volunteers accidentally only given a half-dose the first time they had the injection, followed by a full dose. But none of those were over 55, according to reports, meaning they didn't represent the vulnerable group who will rely on the vaccine in the real world.

Exactly how well the vaccine being developed by Oxford University and AstraZeneca works is not yet clear, because an error in the dosing made it more effective in some people but scientists say there weren't enough people in that group to be sure of the results

Exactly how well the vaccine being developed by Oxford University and AstraZeneca works is not yet clear, because an error in the dosing made it more effective in some people but scientists say there weren't enough people in that group to be sure of the results

Scientists said claiming the vaccine could be 90 per cent effective for everyone based on that chance result was 'shaky science' and its manufacturer, AstraZeneca, yesterday announced it would carry out another clinical trial to confirm the results.

The company's share price has dropped by almost eight per cent since it unveiled the results on Monday amid confusion over whether the dosing error will harm the vaccine's chances of approval. There are doubts about how it will go down in the US, which has pre-ordered 500million doses of the jab.

If the vaccine turns out to be less effective than Pfizer's, Britain could face 'tough choices' about whether to give more people that one, according to one expert.

NO10 DENIES PLANS TO PUT UNION JACK FLAG ON OXFORD'S VACCINE

Downing Street said there were 'no plans' to have the Union flag printed on the Oxford University and AstraZeneca coronavirus vaccine, following reports that Number 10's 'Union Unit' had asked for the British flag to appear on packaging.

The Prime Minister's official spokesman told reporters: 'There are no plans for the Union Jack to be on doses.

'We've said previously the manufacturing for some of the leading potential vaccines is already under way so they can be rolled out quickly if and when approved.

'Manufacturers are well versed in the best ways to package products like this.'

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Professor David Salisbury, a former vaccines director at the Department of Health, said on Radio 4 today: 'If it comes through at 62 per cent and the other vaccines that are coming through so far at 90 per cent then I think you have to think very carefully: what do we with 100million doses of a product that isn't protecting as well as the alternatives?' 

Britain is moving closer by the day to getting a vaccine that could bring an end to the coronavirus outbreak, with public health officials expecting people to start getting appointments in less than two weeks' time.

It comes it was claimed today that suspected North Korean hackers tried to break into the systems of AstraZeneca in recent weeks, as the company races to deploy its vaccine for the Covid-19 virus. 

The hackers posed as recruiters on networking site LinkedIn and WhatsApp to approach AstraZeneca staff with fake job offers, sources said. They then sent documents purporting to be job descriptions that were laced with malicious code designed to gain access to a victim's computer.

Health Secretary Matt Hancock said: 'We are working tirelessly to be in the best possible position to deploy a vaccine as soon as one is approved by the independent regulator the MHRA.

'We have formally asked the regulator to assess the Oxford/AstraZeneca vaccine, to understand the data and determine whether it meets rigorous safety standards. 

'This is an important step towards deploying a vaccine as quickly as safely possible.'

The MHRA will look in detail at the results of the clinical trial run by the Oxford and AstraZeneca team to decide how good their vaccine is.

If the vaccine is provably safe, and protects against Covid-19, the MHRA (Medicines and Healthcare products Regulatory Agency) can grant the Government and NHS power to offer it to members of the public and start vaccinating right away. 

The trial results showed that 30 out of 131 people who caught coronavirus in the study had been given the vaccine, compared to 101 who got a fake vaccine.

England's chief medical officer, Professor Chris Whitty, last night stopped short of giving the vaccine his full support in a TV briefing and said decisions about how good it was should be left to the experts at the MHRA.

In light of confusion about how well the jab protects against coronavirus, AstraZeneca is set to run an additional global trial, according to its chief executive Pascal Soriot.

There has been close scrutiny of the vaccine, after it was found to be 70 per cent effective on average, but 90 per cent effective with a low-dose jab followed by a standard booster injection.

This much higher result, based on a sub-group of around 2,700 people, was met with concern when it emerged no one in the group was reportedly aged over 55.

It is important to establish if the vaccine can work as well in over-55s, who face a greater threat from Covid and have higher death rates.

Instead of adding the trial arm to an ongoing US process, a new trial will evaluate a lower dosage that performed better than a full amount during the firm's studies.

'NORTH KOREAN' HACKERS 'TRY TO BREAK INTO SYSTEMS OF ASTRAZENECA'

Suspected North Korean hackers have tried to break into the systems of British drugmaker AstraZeneca in recent weeks, it was claimed today as the company races to deploy its vaccine for Covid.

The hackers posed as recruiters on networking site LinkedIn and WhatsApp to approach AstraZeneca staff with fake job offers, the sources said. They then sent documents purporting to be job descriptions that were laced with malicious code designed to gain access to a victim's computer.

The hacking attempts targeted a 'broad set of people' including staff working on Covid-19 research, said one of the sources, but are not thought to have been successful.

The North Korean mission to the United Nations in Geneva did not respond to a request for comment from Reuters. Pyongyang has previously denied carrying out cyberattacks. It has no direct line of contact for foreign media.

AstraZeneca, which has emerged as one of the top three Covid-19 vaccine developers, declined to comment.

The sources, who spoke on condition of anonymity to discuss non-public information, said the tools and techniques used in the attacks showed they were part of an ongoing hacking campaign that US officials and cybersecurity researchers have attributed to North Korea.  

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It is thought to have boosted the potential efficacy of the shot to 90 per cent, while it blocked just 70 per cent of infections on average across all branches of the trial.

But the data from that group isn't detailed enough for scientists to be sure, they say.

Head of the US's Operation Warp Speed vaccine development programme, Moncef Slaoui, said: 'There are still a number of variables that we need to understand.'

He said it was possible the better effectiveness in the half-dose group was 'random'. 

But AstraZeneca's research director Sir Mene Pangalos said that even the lower efficacy estimate of 62 per cent was good news.

Announcing another trial to clarify the results yesterday, Sir Mene said: 'Whichever way you cut the data, even if you only believe the full-dose/full-dose data... We still have efficacy that meets the thresholds for approval with a vaccine that's over 60 per cent effective.'

Professor Whitty, who is Chief Medical Adviser to the UK Government, said: 'The simple answer to this is there is always scientific debate about virtually everything.

'The key thing from our point of view is to leave this in the hands of the regulator, the excellent MHRA regulator.

'They will make an assessment with lots of data that is not currently in the public domain on efficacy and on safety and we will see the papers published in peer reviewed journals, which will allow us to make a decision about what needs to happen.

'We need to allow that process to go forward. I think it's always a mistake to make judgement early before we have enough information.'

Chief Scientific Adviser to the UK Government Sir Patrick Vallance was less shy when the question was put to him, saying: 'The headline result is the vaccine works and that's very exciting.'

AstraZeneca is facing tricky questions about its success rate that some experts say could hinder its chances of getting speedy US and EU regulatory approval.

The chief medical officer refused to back it at a Downing Street press conference yesterday (pictured) amid controversy surrounding data from its late-stage trials

The chief medical officer refused to back it at a Downing Street press conference tonight (pictured) amid controversy surrounding data from its late-stage trials

Pictured: A graph showing vaccine orders made by the EU, US, Canada, UK, Japan and Australia. The UK has ordered 40 million units of the Pfizer/BioNTech vaccine

REVEALED: Covid vaccine trials did NOT monitor whether participants took other steps to prevent infection like wearing masks and social distancing

Coronavirus vaccine makers tightly controlled who was enrolled to their trials, their vaccine dosages, the timing of those doses and much more - but they did not monitor participants' other behaviors, like mask-wearing, that affect infection risks.

Trial participants were left to decide for themselves where and how often to wear masks and how to practice social distancing, one told Business Insider. 

And these differences in how coronavirus vaccine trial participants behaved could have drastic effects on how likely people who got the vaccine, versus those who got a placebo, were to get infected. 

Neither Moderna nor Pfizer gave trial participants instructions on how to behave to try to reduce their infection risks (or not), and didn't log ths behaviors either, unless they suspected someone had caught coronavirus. 

It doesn't necessarily mean that the two leading vaccines don't live up to the 90 percent efficacy found by their trials, but it does leave a gap in what we know about how much protection is offered by a shot versus by masking and social distancing. 

And it comes as the results of AstraZeneca's trial for the Oxford University-designed shot come under fire after Oxford acknowledged that it was a manufacturing error that led it to try giving participants a half-dose for their first shot - an accidental arm of the trial that proved most effective.

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Several scientists have raised doubts about the robustness of results after the mistake led to a higher efficacy. 

Running an entirely new trial could delay the approval of the Oxford University vaccine, which some including the WHO deemed the most promising jab.

Chief scientist for the company Mene Pangalos initially defended the results, saying the shot worked 'whichever way you cut the data.'

The CEO later contradicted him and said the firm will likely run a whole new trial to test whether the regimen given a half-strength first dose is really the most effective.

Soriot told Bloomberg: 'Now that we've found what looks like a better efficacy we have to validate this, so we need to do an additional study.'

The 90 per cent figure is being challenged by experts because of the small number of people it was tested on.

Only 2,300 volunteers under-55 were given the smaller dose and none of them were over-55, the most high-risk age group.

In the Moderna and Pfizer vaccine trials - which are about 95 per cent effective - dosing regimens were tested on 10,000 volunteers and four in 10 were over 55.

Dr Pangalos, AstraZeneca's executive vice president for research, batted away criticisms, claiming 'the mistake is actually irrelevant'.

He added: 'Whichever way you cut the data - even if you only believe the full-dose, full-dose data...

'We still have efficacy that meets the thresholds for approval with a vaccine that's over 60 per cent effective.

'I'm not going to pretend it's not an interesting result, because it is - but I definitely don't understand it and I don't think any of us do.'

Pfizer's former president of global research, John LaMattina, has also raised the prospect that the vaccine may not be approved for emergency-use in the US.

Mene Pangalos, AstraZeneca's vice president for research, defended Oxford's Covid-19 vaccine amid mounting criticism

Mene Pangalos, AstraZeneca's vice president for research, defended Oxford's Covid-19 vaccine amid mounting criticism

He tweeted it was it was 'hard to believe' that regulators would give the green light to a vaccine 'whose optimal dose has only been given to 2,300 people'.

The World Health Organization set a target of 50 per cent effectiveness for a Covid-19 jab, a threshold Oxford surpassed after its jab was 60 per cent effective in people receiving two full doses.

But despite this it is facing mounting criticism from scientists.

Hilda Bastian, an accomplished scientist turned writer who blogs for the British Medical Journal, claimed yesterday data from the Oxford trials had been 'patched together' without results from the groups most vulnerable to Covid.

Others warn they 'still don't have all the information that is needed' and that, based on current data, the jab may be rejected for emergency approval by US regulators. 

Oxford's candidate is seen as a potential silver bullet because it costs a fraction of the price of ones from Pfizer and Moderna and does not need to be stored in expensive fridges.

Dr Pangalos said yesterday there was a theoretical rationale for why a lower dose followed by a higher dose could work, reports the Wall Street Journal.

The Oxford vaccine is a genetically engineered common cold virus that used to infect chimpanzees. It has been modified to make it weak so it does not cause illness in people and loaded up with the gene for the coronavirus spike protein, which Covid-19 uses to invade human cells

The Oxford vaccine is a genetically engineered common cold virus that used to infect chimpanzees. It has been modified to make it weak so it does not cause illness in people and loaded up with the gene for the coronavirus spike protein, which Covid-19 uses to invade human cells

'I'm not going to hand wave with the immunologists,' he said.

'(But) until I see some data that gives me some science behind it, I'm going to say 'I don't know'.'

Professor Sarah Gilbert, part of the team behind Oxford's vaccine, said on Monday the smaller earlier dose may 'prime the immune system' to produce a stronger response when it is hit with a bigger dose of the vaccine.

'It may be because that better mimics what happens in a real infection,' she said. 'It could be that giving a small vaccine to start with and following up with a big amount that could be the better way to kick the immune system into action.' 

In a piece for Wired, Ms Bastian said the critical flaw was that a dosing error led to a huge boost in the success rate - experts accidentally gave some volunteers one-and-a-half doses of the jab rather than two full doses that people are meant to get. 

The trials were also never designed to test this hypothesis, which leaves the door open to subconscious biases creeping into the study methods or data, making the study less rigorous.

'I have a tiny sense of pride': Volunteer in Oxford's coronavirus vaccine trial hails 'promising' results 

A volunteer in Oxford University's coronavirus vaccine trial has revealed she felt a 'tiny sense of pride' at taking part in research that could finally beat the virus. 

Sarah Hurst, 47, from South Oxfordshire, said it was a 'great feeling' after hearing on Monday that the vaccine could trigger an immune response in up to 90 per cent of those who receive the jab.

Jack Somers, 35, from London, who also took part, said he was 'very happy' and felt like his vaccine team had 'just won'. 

Sarah Hurst, 47, from Goring-on-Thames, who took part in the trials of the vaccine, said she had a 'tiny sense of pride' in helping to prove the jab worked

Sarah Hurst, 47, from Goring-on-Thames, who took part in the trials of the vaccine, said she had a 'tiny sense of pride' in helping to prove the jab worked

The pair, who both work as journalists, received two shots of either the experimental or placebo vaccine. Mr Somers said he suffered side-effects of a pain in his shoulder and slightly raised temperature, but Ms Somers said she didn't experience any. 

Ms Hurst, who works as a journalist, said: 'It's really the developers and everyone who's done all the work, all the medical students who are constantly all day meeting the vaccine participants and testing them and being on the front line.

'But it's good, it's a great feeling to help to make a vaccine.'

Jack Somers, 35, from London , who also took part, said he was 'very happy' and felt like his vaccine team had 'just won'

Jack Somers, 35, from London , who also took part, said he was 'very happy' and felt like his vaccine team had 'just won' 

Explaining why she signed up, she said: 'I live near where it's being done and they were looking for people in the Thames Valley. As soon as I saw that I wanted to get involved to help research a vaccine.'

She underwent health checks and blood tests before receiving her two shots, and filled in a diary to notify researchers of her movements over the course of the study, as well as any symptoms.

'You have to treat it as if you were in the placebo group anyway, you wouldn't go out and randomly expose yourself because you don't know,' she said.

Despite suffering no side effects, this doesn't mean she received the placebo. The trial used the meningitis vaccine as a control, which scientists argued would elicit a similar response to the Covid-19 jab. 

She said Monday's results were 'promising' and noted 'the fact it doesn't need to be chilled at a very low temperature and is cheaper than the other vaccines will help in making it easier to distribute'.

'You have to treat it as if you were in the placebo group anyway, you wouldn't go out and randomly expose yourself because you don't know,' she said. 

'People have only been vaccinated for a few months so I would still want to know: what are going to be the results after a year? Is it going to be effective after a year?

'That's something you really just have to wait for.'

Mr Somers said he found it hard to believe how quickly scientists had developed the vaccine. 

'I can't help but take my hat off to the scientists,' said the freelance journalist from south-west London.

'I remember six months ago sitting in a hospital watching a safety video, with Professor Matthew Snape at Oxford University talking in quite careful, deliberate, cautious terms about how this vaccine might work or it might not work.

'Now it seems amazing that we're here six months later and that jab is very effective at stopping coronavirus.

'It's not where I thought we'd be six months ago, it's not even where I thought we'd be a month ago, but it's testament to the work of so many people, so many extraordinary people.' 

Volunteers receive no information about how the trial is going so have been following the progress in the media along with everybody else.

And Mr Sommers said that, while he had been very pleased to read about positive results from other vaccines such as that developed by Pfizer, there was a special feeling about this one. 

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She wrote: 'This week's 'promising' results are nothing like the others that we've been hearing about in November [the studies the results are based on were less rigorous] — and the claims that have been drawn from them are based on very shaky science.

'The problems start with the fact that Monday's announcement did not present results from a single, large-scale, Phase 3 clinical trial, as was the case for earlier bulletins about the BNT-Pfizer and Moderna vaccines...

'The fact that they may have had to combine data from two trials in order to get a strong enough result raises the first red flag.... As far as we know, some of this analysis could hinge on data from just a few sick people.'

She said this means the findings could be a coincidence, or they could be 'biased by other factors'.  

The former president for global research at Covid-19 vaccine competitor Pfizere, John LaMattina, has warned based on the current data Oxford's jab is unlikely to be approved for emergency-use in the US. 

He tweeted it was it was 'hard to believe' that regulators would give the green light to a vaccine 'whose optimal dose has only been given to 2,300 people'.

Professor Natalie Bean, a bio-statistician at the University of Florida, told the Financial Times they still 'don't have all the information we need to tell whether these results are reliable'.

'We certainly don't have enough information in the public domain to decide whether this half dose is really working,' she added. 

An investment analyst at SVB Leerink, Geoffrey Porges, told the FT the jab was likely to be rejected because the company had 'tried to embellish their results' by highlighting its effectiveness in a 'relatively small subset of subjects in the study'.

Adding pressure to Oxford's vaccine, a virologist at the Icahn School of Medicine in New York, Florian Krammer, told the New York Times: 'The only thing that you can really say right now is that the vaccine seems to work.'

And added: 'It's just hard to say how well it works compared to others.' 

But Professor Ian Jones, a virologist at the University of Reading, told MailOnline: 'We need to keep the positives in mind, that the vaccine is safe and can provide protection. 

'It is also a fact that in order to see protection, a Phase 3 trial has to be done in an area of current infection and if the level of infection changes, there may be a need to add additional sites.'

He did concede, however, that 'the issue of the dose is confusing'. 

He added: 'That 90 per cent protection was observed in the subset that received the supposed lower dose is really good but I think that would equate to only about 15 people in the 3,000 that received it which may be too low to convince regulators of efficiency, especially if it is not quite clear what the key difference is between it and the higher dose. All this should be much clearer when the full data are published.' 

Oxford University acknowledged yesterday it mistakenly administered a half-dose and full-dose regime to some participants in the study.

They added: 'The methods for measuring the concentration are now established and we can ensure that all batches of vaccine are now equivalent.' 

Oxford's trials found that the jab has a nine in ten chance of working when administered as a half dose first and then a full dose a month later. 

But efficacy drops to mere 62 per cent when someone is given two full doses a month apart.

Oxford has also claimed that its vaccine has an average efficacy of 70 per cent, based on the 62 and 90 per cent figures, which would put the Covid jab on par with good flu vaccines.

But there have been doubts about the reliability of the 70 per cent figure because it has been crudely calculated based on the two regimens, rather than everyone in the trials of all ages. 

And because so far Oxford and AstraZeneca - the British pharmaceutical firm which owns the rights to the jab - have only revealed the percentages in a press release, it is not clear how they arrived at those figures. 

It means the analysis that could seal whether or not the jab is administered to millions of people globally could be based on data from a handful of people - which, again, leaves the door open for other factors to bias in the study.

For example, it has since been revealed that the people who received the reduced dose included no-one over the age of 55 - who are most vulnerable to falling seriously ill or dying from Covid, according to Ms Bastian.

That was not the case for the normal dosed group, raising questions about whether the demographic - rather than dosing - difference is the true driver behind the boosted efficacy. 

The Oxford-AstraZeneca study appears to include few participants over the age of 55, even though the vaccine is being targeted at elderly people. 

Wired reports that people in that demographic were not originally eligible to join the Brazilian trial at all - compared Pfizer's trial, where 41 per cent were over 55. 

Another flaw, according to Ms Bastian, came from the simple fact the results have been combined from two separate trials in the UK and Brazil, as opposed to one single large-scale study like Pfizer and Moderna's vaccines. 

Oxford originally planned to conduct a single trial in the UK when it launched its phase three study in May, but coronavirus began to fizzle out over summer which meant not enough volunteers were getting infected naturally. 

A month later a second phase three trial was started in Brazil where transmission had begun to spike. 

But the consequence of splitting the trial in half was that researchers could not control variables as tightly as they could in one single trial done by the same team.

There wasn't a standardised dosing regimen across both trials and control groups in the studies were not given the same fake vaccine to compare to the Covid jab.

Participants in Brazil were given a saline injection as a placebo, whereas the British arm of the study were given a vaccine for meningitis - which creates an unfair comparison. 

According to emergency-use vaccine guidance issues by Britain's medical regulator, the MHRA, and the FDA in the US, jabs can be approved if they demonstrate safety and efficacy through a single Phase 3 clinical study. 

Although early results from Oxford's clinical trials were published on Monday, the study is not completed.

Hilda Bastian, an accomplished scientist turned writer who blogs for the British Medical Journal (BMJ), claims data from the Oxford trials has been 'patched together'

Hilda Bastian, an accomplished scientist turned writer who blogs for the British Medical Journal (BMJ), claims data from the Oxford trials has been 'patched together'

Oxford has started a 30,000-person phase 3 trial in the US to get more accurate and precise data about its vaccine - but the jab could be approved and rolled out within weeks before those results arrive.

Oxford researchers said they intend to publish the full results of the trial in a medical journal in the coming weeks and will then submit an application to the drugs regulator, the MHRA, for a licence to use the vaccine on members of the public.

This process could then take days or weeks for the MHRA to decide whether the jab is good enough to use before it can start to be given out – this is currently expected to be completed in December.

The vaccine uses a harmless adenovirus to deliver genetic material that tricks the human body into producing proteins known as antigens that are normally found on the coronavirus's surface, helping the immune system develop an arsenal against infection.

Britain has ordered 100 million doses, with almost 20 million due by Christmas. 

The vaccine is expected to cost just £2 per dose and can be stored cheaply in a normal fridge, unlike other jabs made by Pfizer and Moderna that showed similarly promising results last week but need to be kept in ultra-cold temperatures using expensive equipment. 

It's also a fraction of the price, with Pfizer's costing around £15 per dose and Moderna's priced at about £26 a shot. 

HOW DO THE OXFORD, MODERNA AND PFIZER/BIONTECH VACCINES COMPARE? 

Moderna and Pfizer/BioNTech have both released interim results of the final stage clinical trials of their vaccines, with both suggesting they are extremely effective. 

Oxford University has published the findings from its second phase, which show the jab provokes an immune response and is safe to use – it is not yet clear how well it protects against coronavirus in the real world.

Here's how they compare: 

CREATOR:

MODERNA (US)

PFIZER (US) & BIONTECH (DE)

OXFORD UNIVERSITY (UK)

How it works: 

mRNA vaccine – Genetic material from coronavirus is injected to trick immune system into making 'spike' proteins and learning how to attack them.

mRNA vaccine – both Moderna's and Pfizer and BioNTech's vaccines work in the same way.

Recombinant viral vector vaccine – a harmless cold virus taken from chimpanzees was edited to produce the 'spike' proteins and look like the coronavirus.

How well does it work?

94.5% effective (90 positive in placebo group, 5 positive in vaccine group) .

95% effective (160 positive in placebo group, 8 positive in vaccine group).

62% - 90% effective, depending on dosing.

How much does it cost?

Moderna confirmed it will charge countries placing smaller orders, such as the UK's five million doses, between £24 and £28 per dose. US has secured 100million doses for $1.525billion (£1.16bn), suggesting it will cost $15.25 (£11.57) per dose.

The US will pay $1.95bn (£1.48bn) for the first 100m doses, a cost of $19.50 (£14.80) per dose.

Expected to cost £2.23 per dose. The UK's full 100m dose supply could amount to just £223million.

Can we get hold of it?

UK has ordered five million doses which will become available from March 2021. Moderna will produce 20m doses this year, expected to stay in the US. 

UK has already ordered 40million doses, of which 10million could be available in 2020. First vaccinations expected in December.

UK has already ordered 100million doses and is expected to be first in line to get it once approved.

What side effects does it cause? 

Moderna said the vaccine is 'generally safe and well tolerated'. Most side effects were mild or moderate but included pain, fatigue and headache, which were 'generally' short-lived. 

Pfizer and BioNTech did not produce a breakdown of side effects but said the Data Monitoring Committee 'has not reported any serious safety concerns'.

Oxford said there have been no serious safety concerns. Mild side effects have been relatively common in small trials, with many participants reporting that their arm hurt after the jab and they later suffered a headache, exhaustion or muscle pain. More data is being collected.